Investigators Workshops

Dec
05

Investigators Workshop: Epilepsy Surgery in Tuberous Sclerosis Complex: Research Priorities and Study Design

9:00 AM-10:30 AM
APPs
Behavioral Health Providers
Clinicians
Fellows/Trainees
Nurses
Pharmacists
Scientists
Technicians

Moderators: Jurriaan M. Peters, MD, PhD and Floor Jansen, MD

Speakers: Jamie Capal, MD; Jeffrey P. Blount, MD; and Brenda E. Porter, MD, PhD

Learning Objectives

Following participation in this activity, participants will be able to:

  • Discuss the broader goals of epilepsy surgery of TSC, which include reduction of seizure burden and improved neurodevelopmental outcome
  • Develop insight in key controversies in TSC epilepsy surgery, including use of laser interstitial thermotherapy, surgery in multifocal epilepsy, intratuber or perituber origin of seizures, and timing of surgery
  • Identify challenges in the design of a multicenter study of epilepsy surgery of TSC

This workshop addresses research opportunities and challenges associated with study design in epilepsy surgery of tuberous sclerosis complex (TSC).

TSC is a multilesional and dynamic epileptic encephalopathy, which limits surgical success by conventional outcome standards that aim for patients to be completely free from seizure. Recent advances in surgical techniques, better localization tools, and improved developmental outcomes seen with seizure reduction, are changing the surgical landscape in TSC. Speakers present both clinical and technical aspects of epilepsy surgery in TSC, research priorities in the field, and challenges in the design of a multi-institutional study.

This workshop covers:

  1. Goals of TSC epilepsy surgery, including reduction of seizure burden and improved neurodevelopmental outcome
  2. Controversies in TSC epilepsy surgery, including use of laser interstitial thermotherapy, surgery in multifocal epilepsy, intratuber or perituber origin of seizures, and timing of surgery
  3. Challenges in the design of a multicenter study of epilepsy surgery of TSC