Investigators Workshop: Neurostimulation and Neuroimaging of Subcortical Arousal Circuits in Epilepsy
This workshop will address new exciting data and techniques for imaging networks and uncovering mechanisms of therapeutic modulation by subcortical stimulation devices in epilepsy. We will provide a comprehensive update of the neuroscience of arousal and consciousness as a general field, and as applied to epileptic seizure networks, in the context of other altered states such as anesthesia, coma or sleep. Promising findings using high field opto-fMRI and multi-site stimulation in animal models allow unprecedented visualization of cortical and limbic network changes with subcortical stimulation - with ability to modulate seizure threshold or reverse seizure-induced loss of consciousness.
Following participation in this activity, participants will be able to:
- Recognize similarities and differences in cortical-subcortical arousal mechanisms in epileptic seizures, anesthesia and sleep
- Describe high field functional neuroimaging methods in animal models combined with optogenetics and multi-site neurostimulation
- Discuss and assess the translational potential of subcortical stimulation devices to prevent or reverse loss of consciousness during seizures, modulate seizure susceptibility, and improve epilepsy comorbidities in patients with refractory epilepsy
Moderator: Melanie Boly, PhD
Speakers: Melanie Boly, PhD; Jin Hyung Lee, PhD; and Hal Blumenfeld, MD, PhD