Investigators Workshop: Sleep and Circadian Rhythms in SUDEP: Disentangling Night-time Contributors to Seizure-associated Death
Moderators: Gordon F. Buchanan, MD, PhD and Franck Kalume, PhD
Speakers: Judy S. Liu, MD, PhD; Benton S. Purnell, BA; and Jiyun Ryu
Following participation in this activity, participants will be able to:
- Discuss the independent roles of sleep and circadian rhythms in contributing to SUDEP risk, and the need for novels methodologies to disentangle these contributions
- Discuss the independent influences of sleep and circadian rhythms on breathing, especially in relationship to a seizure
- Recognize the current state of animal models for the study of sleep and circadian rhythms in seizures, epilepsy, and SUDEP
This workshop presents crucial factors of sleep and circadian rhythms in SUDEP.
The role of sleep and circadian rhythms may contribute to increased risk for SUDEP in patients with epilepsy. Attendees learn the latest evidence on disentangling sleep contributors from seizure-related fatalities.
This session covers:
- The current knowledge of molecular regulation of circadian rhythms, circadian regulation of seizures, seizure threshold, and brainstem functions such as cardiovascular and respiratory function
- How animal models will help understand these mechanisms with a focus on identifying novel ways to disentangle sleep and circadian rhythms in understanding day-night differences in seizures, epilepsy, and SUDEP