Investigators Workshop: Using Human Brain Organoids to Study Genetic Epilepsies
Moderator: Jack M. Parent, MD
Speakers: Helen Bateup, PhD; Ranmal A. Samarasinghe, MD, PhD; and Andrew M. Tidball, PhD
Following participation in this activity, participants will be able to:
- Describe different human brain organoid methods used to model genetic epilepsies
- Discuss the advantages and challenges of using brain organoids to model epilepsies
- Identify epilepsy relevant phenotypes in brain organoids expressing epilepsy mutations
This workshop investigates advances in human brain organoids in the study of genetic epilepsy.
The brain organoid field is advancing rapidly and offers a novel three-dimensional culture approach to study genetic neurodevelopmental disorders and epilepsies. This workshop addresses the application of human brain organoid methods to model genetic epilepsies.
This session covers:
- Advances in brain organoid, including fusions of patterned excitatory and inhibitory organoids to model interneuron development and network integration, as well as the addition of non-neuronal cell types to organoids to more faithfully recapitulate human brain development
- Techniques to study genetic epilepsies that include mTORopathies, Rett syndrome and ion channelopathies
- Advantages and challenges of brain organoid modeling